某院铜绿假单胞菌感染的临床分布及耐药菌情况分析

张红英，李兰英

（陕西省渭南市第二医院，陕西 渭南，714000）

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摘要：

目的 探讨某院铜绿假单胞菌感染的临床分布及耐药菌情况。方法 选择某医院住院患者中检测出的210 例铜绿假单 胞菌感染标本，了解其科室来源及标本类型分布状况，并实施药敏试验，了解标本的耐药性及对常见抗菌药物的耐药率。 结果 标本科室来源：ICU 占比最高（29.0%），其次为呼吸内科、泌尿外科。标本来源类型：痰液占比最高（71.4%），其次为伤口分泌物。耐药性检测结果：多药耐药铜绿假单胞菌检出率为12.4%，泛耐药铜绿假单胞菌检出率为5.7%。ICU 病房中多药耐药铜绿假单胞菌、泛耐药铜绿假单胞菌检出率高于其他病房（P<0.05）。药敏检测结果：铜绿假单胞菌对头孢噻肟耐药性最高（70.5%），其次为头孢曲松（64.3%）。铜绿假单胞菌对头孢他啶、美罗培南、头孢哌酮舒巴坦、哌拉西林他唑巴坦、阿米卡星、头孢吡肟、亚胺培南的耐药性较低，均≤33.3%；铜绿假单胞菌对头孢哌酮舒巴坦的耐药性最低（19.0%）。结论 ICU和呼吸内科 是铜绿假单胞菌感染的主要科室，临床需不断加强抗生素的合理使用。

关键词：医院；铜绿假单胞菌感染；耐药菌

中图分类号：R446.5文献标志码：A文章编号：2096-1413(2017)30-0108-02

Clinical distribution of Pseudomonas aeruginosa infection and analysis of drug-resistant bacteria in a hospital
ZHANG Hong-ying, LI Lan-ying
(the Second Hospital of Weinan, Weinan 714000, China)

ABSTRACT: Objective To investigate the clinical distribution and drug resistance status of Pseudomonas aeruginosa infection in a hospital. Methods Two hundred and ten cases of Pseudomonas aeruginosa infection were detected in a hospital of hospitalized patients, and the status of the department and the type of the specimen were analyzed, and drug susceptibility testing was implemented, so as to understand the drug resistance and the resistance to common antimicrobial agents. Results Specimen department source: ICU accounted for the highest (29.0%), followed by respiratory medicine, urology. Specimen source type: sputum accounted for the highest (71.4% ), followed by wound secretions. The drug resistance test results showed that multidrug-resistant Pseudomonas aeruginosa detection rate was 12.4%, and pan-resistant Pseudomonas aeruginosa detection rate was 5.7%. The detection rate of multidrug-resrstant Pseudomonas aeruginosa and pan-resistant Pseudomonas aeruginosa in ICU ward were higher than those in other wards (P<0.05). The drug resistance results showed that Pseudomonas aeruginosa had the highest resistance to cefotaxime (70.5%), followed by ceftriaxone (64.3%). Pseudomonas aeruginosa was less resistant to ceftazidime, meropenem, cefoperazone sulbactam, piperacillin tazobactam, amikacin, cefepime, imipenem, the resistance rates were ≤33.3%. Pseudomonas aeruginosa had the lowest resistance to cefoperazone sulbactam (19.0% ). Conclusion ICU and respiratory medicine are the main departments of Pseudomonas aeruginosa infection, it needs to continue to strengthen the rational use of antibiotics.
KEYWORDS: hospital; Pseudomonas aeruginosa infection; drug resistant bacteria

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