盐酸氟西汀与文拉法辛治疗产后抑郁的临床疗效比较

李鸿远1 ，罗美英2

（陕西省汉中市勉县县医院：1.神经内科；2.妇产科，陕西 汉中，724207）

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摘要：

目的 探讨盐酸氟西汀与文拉法辛治疗产后抑郁的临床效果。方法 选择2013年8月至2016年8月在我院就诊的产后抑郁症患者60例，依据患者入院顺序，使用随机对照表将患者分为对照组30例和观察组30例，分别对两组患者应用盐酸氟西汀和文拉法辛治疗，比较两组的治疗效果。结果 治疗后两组患者的HAMD评分均有所降低，但两组比较差异不显著（P>0.05）；两组的治疗总有效率比较，差异没有统计学意义（P>0.05）；治疗期间两组均未出现严重的不良反应，两组不良反应发生率比较，无显著性差异（P>0.05）。结论盐酸氟西汀与文拉法辛治疗产后抑郁均具有较好的效果，可较高的改善患者的 症状，两组药物的安全性相当。

关键词：盐酸氟西汀；文拉法辛；产后抑郁

中图分类号：R749.4 文献标志码：A文章编号：2096-1413(2017)30-0096-02

Comparison of clinical efficacy of fluoxetine hydrochloride and venlafaxine in the treatment of postpartum depression
LI Hong-yuan 1, LUO Mei-ying 2
(1. Department of Neurology; 2. Department of Obstetrics and Gynecology, Mian County Hospital, Hanzhong 724207, China)

ABSTRACT: Objective To investigate the clinical effect of fluoxetine hydrochloride and venlafaxine in the treatment of postpartum depression. Methods Sixty patients with postpartum depression from August 2013 to August 2016 in our hospital were selected and divided into control group (30 cases) and observation group (30 cases) according to the order of admission. The two groups were treated with fluoxetine hydrochloride and venlafaxine respectively, and the therapeutic effect between the two groups was compared. Results The HAMD scores of two groups were decreased after treatment, but there was no significant difference between the two groups (P>0.05). The total effective rate of the two groups was not statistically significant (P>0.05). There was no serious adverse reaction in the two groups during the treatment period, the incidence of adverse reactions between the two groups had no significant difference (P>0.05). Conclusion Fluoxetine
hydrochloride and venlafaxine have a good effect in the treatment of postpartum depression, which can improve the symptoms of the patients and have considerable safety.
KEYWORDS: fluoxetine hydrochloride; venlafaxine; postpartum depression

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