不同甲氨蝶呤与米非司酮方案治疗异位妊娠的临床效果

张金玲1，李淑杏2

（1.商洛市疗养院，陕西 商洛，726000；2.商洛市第二人民医院，陕西 商洛，726000）

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摘要：

目的 分析异位妊娠患者应用甲氨蝶呤与米非司酮不同方案治疗的临床效果。方法 将我院2014年2月至2016年5月收治的80例异位妊娠患者按随机数字表法分为A、B 组，各40 例。A 组采用分次肌注甲氨蝶呤+口服米非司酮治疗，B 组采用单次肌注甲氨蝶呤+口服米非司酮治疗。比较两组患者的治疗情况。结果 两组患者各时段β-HCG 下降率比较，差异不显著（P>0.05）；B 组不良反应总发生率为12.50%，治疗总有效率为97.50%，明显优于A 组的32.50%、72.50%，差异具有统计学 意义（P<0.05）。结论 单次肌注甲氨蝶呤+口服米非司酮治疗异位妊娠效果确切，不良反应发生率较低，临床应用价值高。

关键词：异位妊娠；甲氨蝶呤；米非司酮；不同方案

中图分类号：R714.22文献标志码：A文章编号：2096-1413(2017)29-0059-02

Clinical effects of different methotrexate and mifepristone programs on ectopic pregnancy
ZHANG Jin-ling 1，LI Shu-xing 2
(1. Shangluo Sanatorium, Shangluo 726000; 2. the Second People``s Hospital of Shangluo, Shangluo 726000, China)

ABSTRACT: Objective To analyze the clinical effects of different methotrexate and mifepristone programs on ectopic pregnancy. Methods Eighty cases of ectopic pregnancy patients in our hospital from February 2014 to May 2016 were divided into A, B group according to the random number method, with 40 cases in each group. The group A was treated with fractional intramuscular injection of methotrexate + oral mifepristone, the group B was treated with single intramuscular injection of methotrexate + oral mifepristone. The treatment effects of the two groups were compared. Results There was no significant difference in the descent rate of β-HCG between the two groups in each time period (P>0.05). The total incidence rate of adverse reactions was 12.50%, and the total effective rate was 97.50% in the group B, which were significantly better than 32.50%, 72.50% in the group A (P<0.05). Conclusion Single intramuscular injection of methotrexate + oral mifepristone in the treatment of ectopic pregnancy has significant effect, and has lower incidence of adverse reactions, which has high clinical application value.
KEYWORDS: ectopic pregnancy; methotrexate; mifepristone; different programs

参考文献：
[1] 罗丹,钟玲,赵腾飞,等.甲氨蝶呤联合米非司酮与单用甲氨蝶呤治 疗异位妊娠的疗效评价[J].解放军医学杂志,2013,36(2):184-187.
[2] 张艳环.甲氨蝶呤联合米非司酮治疗异位妊娠的临床疗效分析[J]. 中国医药指南,2013,11(8):1782-1783.
[3] 徐芳.甲氨蝶呤联合米非司酮治疗异位妊娠的疗效观察[J].中国实用医药,2013,8(14):195-196.
[4] 张国琼.甲氨蝶呤联合米非司酮治疗异位妊娠的作用探讨[J].河北医学,2015,21(8):1439-1441.
[5] 侯爱贞.甲氨蝶呤联合米非司酮不同方案治疗异位妊娠的疗效探讨[J].中外医疗,2015,35(18):108-109.
[6] 白素芳,刘云婷,张伟芬,等.甲氨蝶呤联合米非司酮治疗异位妊娠临床研究[J].海南医学院学报,2015,21(12):1661-1663.
[7] 聂爱宏.甲氨蝶呤两种应用方案联合米非司酮治疗异位妊娠的临床研究[J].中国医学创新,2013,32(36):22-24.
[8] 吴冬.甲氨蝶呤两种应用方案与米非司酮联合治疗异位妊娠的效果观察[J].河南医学研究,2013,22(1):81-82.
[9] 刘娟波,吴燕萍,李艳虹,等.甲氨蝶呤不同给药方式配伍米非司酮治疗异位妊娠的临床疗效对比[J].湖南师范大学学报:医学版,2013,10(4):52-54,59.
[10] 靳露佳.甲氨蝶呤配伍米非司酮保守治疗高血β-HCG 值异位妊娠的药效观察及给药方式分析[J].中国医药指南,2013,11(3):202-203.
[11] 陆志红,倪南鹰.不同甲氨蝶呤应用方案联合米非司酮治疗异位 妊娠的对照研究[J].医药前沿,2013,3(33):90-91.