不同剂量泮托拉唑联合奥曲肽治疗消化性溃疡并消化道出血的临床效果比较

慕亚梅

（延安市博爱医院，陕西 延安，716000）

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摘要：

目的 探究不同剂量泮托拉唑联合奥曲肽治疗消化性溃疡并消化道出血的临床疗效。方法 选择2015年2月至2016年 8月在我院就诊的140例消化性溃疡并消化道出血患者，将所有患者随机分为对照组与观察组，各70例。对照组实施低剂量 泮托拉唑联合奥曲肽治疗，观察组实施大剂量泮托拉唑联合奥曲肽治疗。比较两组各项临床指标及临床疗效，并记录治疗过程中两组不良反应发生情况。结果 观察组输血量、止血时间、住院时间均优于对照组（P<0.05）；观察组治疗总有效率为 95.71%，高于对照组的84.29%（P<0.05）；两组患者再出血率及不良反应发生率比较，差异无统计学意义（P>0.05）。结论 采用大剂量泮托拉唑联合奥曲肽治疗消化性溃疡并消化道出血，能有减少输血量，缩短治疗时间，提高临床疗效，安全性较高。

关键词：泮托拉唑；奥曲肽；消化性溃疡；消化道出血

中图分类号：R573.1文献标志码：A文章编号：2096-1413(2017)29-0045-02

Clinical effect comparison of different doses of pantoprazole combined with octreotide in the treatment of

peptic ulcer and gastrointestinal bleeding
MU Ya-mei
(Bo``ai Hospital of Yan``an, Yan``an 716000, China)

ABSTRACT: Objective To investigate the clinical efficacy of different doses of pantoprazole combined with octreotide in the treatment of peptic ulcer and gastrointestinal bleeding. Methods A total of 140 patients with peptic ulcer and gastrointestinal bleeding in our hospital from February 2015 to August 2016 were randomly divided into control group and observation group, with 70 cases in each group. The control group was given low dose of pantoprazole combined with octreotide, the observation group was given high dose of pantoprazole combined with octreotide. The clinical indexes and clinical efficacy of the two groups were compared, the adverse reactions of the two groups during treatment were recorded. Results The transfusion volume, hemostatic time, hospital stays of the observation group were better than those of the control group (P<0.05); the total effective rate of the observation group was 95.71%, which was higher than 84.29% of the control group (P<0.05); there were no statistical differences in rebleeding rate and incidence of adverse reactions between the two groups (P>0.05). Conclusion High dose of pantoprazole combined with octreotide in the treatment of peptic ulcer and gastrointestinal bleeding can reduce transfusion volume, shorten treatment time, increase clinical efficacy, which has higher safety.
KEYWORDS: pantoprazole; octreotide; peptic ulcer; gastrointestinal bleeding

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