口服抗高血压药物临床应用调查分析

齐永红1，贾秋玲2

（1.陕西省康复医院，陕西 西安，710065；2. 西安医学院附属宝鸡医院，陕西 宝鸡，721006）

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摘要：

目的 研究2015年1月至12月西安市某三甲医院住院高血压病患者口服抗高血压药物的用量及各类降压药物的联合应用情况，探讨口服抗高血压药物应用的合理性。方法 采用回顾分析法、用药频度（DDDs）排序法、金额排序法及Excel 软件对患者基本信息、药物品种、销售金额、用药频度等指标进行统计分析。结果 215 例患者中60岁以上老年患者占61.86%；111 名男性患者中，既往有饮酒、吸烟史者各占50%左右；既往有高血压病史者190例，占比88.37%，坚持长期服药的有82例，其中血压控制良好的占59.76%。2015年住院高血压病患者使用口服抗高血压药物金额居前3位的品种依次为钙离子通 道阻滞剂、血管紧张素域受体拮抗剂、血管紧张素转化酶抑制剂；用药频度居前3位的药物依次是马来酸依那普利片、硝苯地平缓释片、马来酸左旋氨氯地平片；单品种用药和二联用药占比73.02%。常见合并症用药包括脑梗塞（28例）、冠心病（54例）、糖尿病（62例）、肾脏疾病（21例）。结论 该院住院患者抗高血压药物的使用情况基本合理，但仍需进一步完善。

关键词：抗高血压药；用药频度；联合用药；合理用药

中图分类号：R972文献标志码：A文章编号：2096-1413(2017)27-0107-04

Analysis of the clinical application of oral antihypertensive drugs
QI Yong-hong 1, JIA Qiu-ling 2
（1. Shaanxi Kangfu Hospital, Xi``an 710065; 2. Affiliated Baoji Hospital of Xi``an Medical College, Baoji 721006, China）

ABSTRACT：Objective To study the usage quantity of oral antihypertensive drug and the joint application of the antihypertensive drug in inpatients with hypertension in a Grade III-class hospitals in Xi``an from January to December in 2015, and to study the rationality of oral antihypertensive drugs. Methods Retrospective analysis, frequency of drug use (DDDs) sorting method and sum of money method and Excel software were used to analyze the basic information of the patients, drug varieties, sales amount and DDDs. Results Of the 215 patients, 60 years old or older accounted for 61.86%; among the 111 male patients, about 50% had previous history of drinking and smoking; there were 190 cases with hypertension history, accounting for 88.37%; there were 82 cases of long-term medication, 59.76% of which had good blood pressure control. In 2015, varieties of oral antihypertensive drugs amounted to the top 3 in hypertensive patients were calcium channel blockers, angiotensin II receptor antagonists and angiotensin converting enzyme inhibitors; durgs of the top 3 DDDs were enalapril maleate tablets, extended release nifedipine tablets, levoamlodipine maleate tablets. Single drug use and two combined use accounted for 73.02% ; common complications in application of oral antihypertensive drugs included cerebral infarction (28 cases), coronary heart disease (54 cases), diabetes mellitus (62 cases), and kidney disease (21 cases). Conclusion The usage of oral antihypertensive drugs of inpatients is basically reasonable, but it still needs to be further improved.
KEYWORDS：antihypertensive drugs; DDDs; combined use of drugs; rational use of drugs

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