高危型人乳头瘤病毒负荷量与宫颈病变的关系研究

张慧泉1，郑时学2

（1.陕西省商洛市镇安县人民医院妇产科，陕西 商洛，711500；2.陕西省商洛市镇安县云盖寺镇 中心卫生院计划生育科，陕西 商洛，711511）

浏览次数：82次 下载次数：355次

摘要：

目的 探讨高危型人乳头瘤病毒负荷量与宫颈病变的关系。方法 选择2013年10月至2016年10月在我院妇科进行高危型人乳头瘤病毒负荷量检测的2 538 例患者，按照患者病毒负荷量将其分为三组：1～100 pg/mL 设为A组；101～500 pg/mL 设为B组；>500 pg/mL 设为C组。统计和记录796例阳性感染病变患者的宫颈病变情况。结果 796例阳性感染病变患者中， 经病理检查确诊为412例。其中，宫颈炎253例，宫颈上皮内瘤变150例，宫颈癌9例。在宫颈病变患者中，相比宫颈炎和上皮内瘤变，宫颈癌的HPV负荷量最高（P<0.05）；C组的宫颈癌发病率明显高于A、B 组，差异具有统计学意义（P<0.05）。结论 高危型人乳头瘤病毒负荷量和宫颈病变有着密切的关系，且随着患者年龄的增加，出现宫颈瘤样变和癌变的风险越大。

关键词：高危型人乳头瘤病毒；宫颈病变；负荷量；诊断价值

中图分类号：R737.33文献标志码：A文章编号：2096-1413(2017)27-0024-02

Study on the relationship between high risk human papillomavirus load and cervical lesions
ZHANG Hui-quan 1, ZHENG Shi-xue 2
(1. Department of Obstetrics and Gynecology, Zhen``an County People``s Hospital, Shangluo 711500; 2. Family Planning Department, Yungaisi Town Health Center of Zhen``an County, Shangluo 711511, China)

ABSTRACT: Objective To study the relationship between high risk human papillomavirus load and cervical lesions. Methods From October 2013 to October 2016 in our hospital, 2 538 patients with high risk HPV load were examined, which were divided into three groups according to their viral load: 1-100 pg/mL was set as the group A; 101~500 pg/mL was set as the group B; > 500 pg/mL was set as the group C. The cervical lesions in 796 patients with positive infection were recorded. Results Of the 796 patients with positive infection, 412 cases were confirmed by pathological examination. Among them, 253 cases were cervicitis, 150 cases were cervical intraepithelial neoplasia, 9 cases were cervical cancer. In cervical disease patients, compared with cervicitis and intraepithelial neoplasia, the HPV load of cervical cancer was the highest (P<0.05). The incidence rate of cervical cancer in the group C was higher than that in the group A and group B (P<0.05). Conclusion There is a close relationship between the risk of HPV and the cervical lesions, and the risk of cervical neoplasia and canceration is increasing with the increase of the patients`` age.
KEYWORDS: high risk human papillomavirus; cervical lesions; load; diagnostic value

参考文献：
[1] 岑坚敏,钱德英,曾仁海,等.高危型人乳头瘤病毒负荷量与宫颈癌及癌前病变的相关性研究[J].中国实用妇科与产科杂志,2007,23(7):533-535.
[2] 梁欣,黄锐,吴绮霞.高危型人乳头瘤病毒的病毒负荷量与宫颈癌及其癌前病变的关系[J].肿瘤药学,2013,3(5):353-354.
[3] 杨亮亮,朱义保.高危型人乳头瘤病毒负荷量与宫颈病变的关系研究[J].实用妇产科杂志,2015,31(4):282-283.
[4] 张文璎,薛月珍,韩玲,等.高危型人乳头瘤状病毒负荷量与宫颈病变严重程度的关系[J].上海交通大学学报:医学版,2007,27(11):1354-1357.
[5] 吴佳皓,吴丹,王弓力,等.高危型人乳头瘤病毒负荷量与各级宫颈病变的关系[J].中国临床医学,2009,16(3):410-412.
[6] 杨静,罗军.宫颈病变进展与高危型人乳头瘤病毒负荷量相关性研究[J].实用预防医学,2010,17(4):646-648.
[7] 刘爱民,黄淑晖,姚丽风,等.高危型人乳头瘤病毒负荷量与宫颈病变的关系研究[J].中国当代医药,2016,23(10):123-125.
[8] 邹冰玉,浦海鹰,李丹,等.210 例高危型人乳头瘤病毒感染检测及宫颈病变影响因素的探讨[J].实用妇产科杂志,2013,29(12):938-940.
[9] 王建捷,靳家玉,冯玲,等.人乳头瘤病毒负荷量与宫颈病变关系的研究[J].临床和实验医学杂志,2013,12(20):1642-1645.
[10] 来永静,戴淑真,初慧君,等.高危型人乳头瘤病毒负荷量检测合并年龄因素在宫颈病变筛查中的作用[J].肿瘤防治研究,2011,38(5):542-544.