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主管:陕西省卫生健康委员会
主办:西安心身医学研究所
   西安交通大学第一附属医院
国际标准刊号:ISSN2096—1413
国内统一刊号:CN61—1503/R

磁共振相对脑血容量(r-CBV)与胶质母细胞瘤疗效的相关性分析

王翠英

(河北省衡水市第四人民医院,河北 衡水,053000)

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摘要:

目的 分析磁共振相对脑血容量(则原悦月灾)与胶质母细胞瘤疗效的相关性。方法 选取2012年5月至2014 年2月我院收治的56例胶质母细胞瘤患者为研究对象。同步放化疗阶段,从放疗第1 天开始给予患者替莫唑胺75 mg/(m2·d)口服;从放疗第4周开始给予患者贝伐珠单抗10 mg/kg,在第1 天和第15天经静脉给药,28 d 为一周期,治疗6个周期。间歇4周给予替莫唑胺辅助治疗。分析T3间期相对脑血容量(r-CBV),然后通过研究56例患者相对脑血容量(r-CBV),将患者分为高值 组及低值组,探索T3间期相对脑血容量(r-CBV)与患者临床疗效的相关性。结果 56例患者均完成6个周期的治疗。高值组患者治疗后6、12、24个月ORR分别为78.57%、57.14%、50.00%;低值组患者治疗后6、12、24 个月ORR分别为78.57%、78.57%、71.43%。低值组患者12、24个月ORR明显高于高值组,差异有统计学意义(P<0.05)。结论 胶质母细胞瘤患者相对脑 血容量(r-CBV)值与患者近期疗效呈负相关,可用来评价肿瘤的预后。
 

关键词:磁共振相对脑血容量(r-CBV);胶质母细胞瘤;客观缓解率

中图分类号:R739.41 文献标志码:A文章编号:2096-1413(2017)27-0012-02

    Correlation analysis of magnetic resonance relative cerebral blood volume (r-CBV) and curative effect of glioblastoma
    WANG Cui-ying
    (the No.4 People``s Hospital of Hengshui, Hengshui 053000, China)

    ABSTRACT: Objective To investigate the correlation of magnetic resonance (MRI) relative cerebral blood volume (r-CBV) and curative effect of glioblastoma. Methods A total of 56 glioblastoma patients admitted in our hospital from May 2012 to February 2014 were selected as the study objects. In concurrent chemoradiotherapy, all the patients received temozolomide 75 mg/(m2·d) orally at the first day of radiotherapy. From the 4th week of the radiotherapy, patients were treated with bevacizumab 10 mg/kg through intravenous administration at the 1st and 15th day of radiotherapy, 28 days as a cycle, the treatment was 6 cycles. The temozolomide was given after 4 weeks intervals as the adjuvant therapy. The relative cerebral blood volume (r-CBV) at T3 were analyzed, and 56 patients were divided into high value group and low value group according to the relative cerebral blood volume (r-CBV). The correlation of magnetic resonance (MRI) relative cerebral blood volume (r-CBV) at T3 and curative effect of glioblastoma was explored. Results Fifty-six patients completed 6 cycles of treatment. The ORR of the high value group at 6, 12 and 24 months were 78.57%, 57.14%, 50.00%, and those of the low value group were 78.57%, 78.57%, 71.43% respectively, the ORR of the low value group at 12, 24 months were higher than those of the high value group, the differences were statistically significant (P<0.05). Conclusion The magnetic resonance (MRI) relative cerebral blood volume (r-CBV) is negatively correlated with the short-term outcome of the patients, which can be used to evaluate the prognosis of patients with glioblastoma.
    KEYWORDS: relative cerebral blood volume (r-CBV); glioblastoma; objective response rate

    参考文献:
    [1] WEN PY,MACDONALD DR,REARDON DA,et al.Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group[J].J Clin Oncol,2010,28(11):1963-1972.
    [2] SCHNEIDER T,MAWRIN C,SCHERLACH C,et al.Gliomas in adults. [J].Dtsch Arztebl Int,2010,107(45):799-807.
    [3] 陆娜,冯晓源,何慧瑾.脑肿瘤的MR 诊断进展[J].磁共振成像,2011,2(1):71-74.
    [4] 江晶晶,谈晓飞,张顺,等.磁共振灌注加权成像与扩散张量成像在脑胶质瘤分级诊断中的应用[J].中华实验外科杂志2014,31(7):1585-1587.
    [5] 张晓琦,李永丽,窦社伟,等.动态对比增强MRI 在胶质母细胞瘤与脑转移瘤鉴别诊断中的应用[J].中华放射学杂志2015,49(6):410-413.

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