多索茶碱联合环丙沙星治疗慢性阻塞性肺气肿的疗效观察

王彦雄

（陕西省清涧县中医医院内科，陕西 榆林，718399）

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摘要：

目的 观察多索茶碱联合环丙沙星治疗慢性阻塞性肺气肿的疗效。方法 选取2014年6月至2016年6月在我院治疗的慢性阻塞性肺气肿患者62例作为研究对象，将其随机分为观察组和对照组，每组31例。对照组患者使用多索茶碱进行治疗，观察组患者使用多索茶碱联合环丙沙星进行治疗。对比两组患者治疗前、后的肺功能指标以及血气指标。结果 治疗前，两组患者的FEV1、FVC、MMEF、PaO₂、pH 以及PaCO₂ 比较，差异均不显著（P>0.05）；治疗后，两组患者的FEV1、FVC、MMEF均较治疗前显著升高（P<0.05），且观察组患者的FEV1、FVC、MMEF均显著高于对照组（P<0.05）；两组患者的PaO₂、pH较治疗前显著提高，PaCO₂ 较治疗前显著降低（P<0.05），观察组患者的各血气指标均显著优于对照组（P<0.05）。结论 多索茶碱联合环丙沙星治疗慢性阻塞性肺气肿的临床疗效显著，具有较高的临床应用价值。

关键词：多索茶碱；环丙沙星；慢性阻塞性肺气肿

中图分类号：R563.9 文献标志码：A文章编号：2096-1413(2017)25-0047-02

The curative effect observation of doxofylline combined with ciprofloxacin in the treatment of chronic

obstructive pulmonary emphysema
WANG Yan-xiong
（Department of Internal Medicine, Qingjian County Hospital of Traditional Chinese Medicine, Yulin 718399, China）

ABSTRACT: Objective To observe the curative effect of doxofylline combined with ciprofloxacin in the treatment of chronic obstructive pulmonary disease. Methods Sixty-two cases of patients with chronic obstructive pulmonary emphysema in our hospital from June 2014 to June 2016 were selected as the objects. According to the simple randomized methods, the patients were divided into control group and observation group, with 31 cases in each group. The control group was given doxofylline treatment, the observation group was given doxofylline combined with ciprofloxacin treatment. After treatment, the pulmonary function and blood gas indexes of the two groups were compared. Results Before treatment, the differences in FEV1, FVC, MMEF, PaO₂, pH and PaCO₂ between the two groups were not significant (P>0.05); after treatment, FEV1, FVC and MMEF in the two groups were significantly higher than those before treatment (P<0.05), and FEV1, FVC and MMEF in the observation group were significantly higher than those in the control group (P<0.05); the PaO₂ and pH of the two groups were significantly higher than those before treatment, and PaCO₂ was significantly lower than that before treatment (P<0.05), and the indexes of blood gas in the observation group were significantly better than those in the control group (P<0.05). Conclusion Doxofylline combined with ciprofloxacin in the treatment of patients with chronic obstructive pulmonary emphysema has remarkable effect and high clinical value.
KEYWORDS: doxofylline; ciprofloxacin; chronic obstructive emphysema

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