小儿轮状病毒肠炎经消旋卡多曲联合葡萄糖酸锌治疗的临床研究
张小军1 ，郭艳2，李光3 ，高谢琼1，李小溪1
（长庆油田职工医院：1.消化内科；2.内分泌科；3.儿科，陕西 西安，710201）
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摘要：
目的 探讨小儿轮状病毒肠炎经消旋卡多曲联合葡萄糖酸锌治疗的临床效果。方法 选取我院收治的410例小儿轮状病毒肠炎患儿进行研究，以治疗方式的不同将患儿分为对照组（205例）和观察组（205例），所有患儿均采用常规治疗，对照组同时行消旋卡多曲治疗，观察组则在对照组治疗的基础上加行葡萄糖酸锌治疗，对比两组患儿的治疗效果。结果 采用不同方式治疗后，观察组患儿的呕吐停止时间、大便性状恢复时间及大便次数恢复时间均明显短于对照组（P<0.05）；且观察组患儿临床治疗总有效率及病毒转阴率均明显优于对照组（P<0.05）。结论 采用消旋卡多曲与葡萄糖酸锌联合方式对小儿轮状病毒肠炎患儿进行治疗效果显著，可促进患儿临床症状改善，具有较高的推广应用价值。
关键词：小儿轮状病毒肠炎；消旋卡多曲；葡萄糖酸锌
中图分类号：R725.1 文献标志码：A文章编号：2096-1413(2017)22-0047-02
Clinical study of racecadotril combined with zinc gluconate on infantile rotavirus enteritis
ZHANG Xiao-jun 1, GUO Yan 2, LI Guang 3, GAO Xie-qiong 1, LI Xiao-xi 1
(1. Department of Gastroenterology; 2. Department of Endocrinology; 3. Department of Pediatrics, Changqing Oilfield Staff
Hospital, Xi``an 710201, China)
ABSTRACT: Objective To investigate the clinical effect of racecadotril combined with zinc gluconate on infantile rotavirus enteritis. Methods A total of 410 cases of children with infantile rotavirus enteritis in our hospital were studied and divided into control group (205 cases) and observation group (205 cases) according to different treatment methods, all the patients received conventional treatment, and the control group received racecadotril, while the observation group accepted zinc gluconate on the basis of the control group. The efficacy of the two groups were compared. Results After different treatment methods, the vomiting stop time, stool recovery time and stool recovery time in the observation group were shorter than those in the control group (P<0.05); and the total effective rate and negative-converting rate in the observation group were significantly better than those in the control group (P<0.05). Conclusion Racecadotril combined with zinc gluconate applied in infantile rotavirus enteritis has obvious treatment effect, which can promote the improvement clinical symptoms in children, it has high value of popularization and application.
KEYWORDS: infantile rotavirus enteritis; racecadotril; zinc gluconate
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