喉癌保留喉功能手术治疗的临床疗效和安全性

白鹏

（陕西省富平县医院，陕西 渭南，711700）

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摘要：

目的 探讨喉癌保留喉功能手术治疗的临床疗效和安全性。方法 选取在我院进行手术治疗的喉癌患者86例为研究对象，随机分为观察组和对照组，各43例。对照组患者实施全喉切除术，观察组患者采用喉部分切除术。比较两组患者炎性因子水平、并发症发生情况、拔管率、生存率及复发率。结果 术后7 d，观察组患者IL-6、ESR 及CRP水平明显低于对照组（P<0.05）。观察组并发症发生率为2.33%，明显低于对照组的18.60%；观察组拔管率为88.37%，明显高于对照组的69.77%（P<0.05）。观察组3、5年生存率分别为88.37%、74.42%，均明显高于对照组的69.77%、53.49%（P<0.05）；两组患者3、5 年复发率比较，差异无统计学意义（P>0.05）。结论 给予喉癌患者保留喉功能手术治疗，可有效减轻手术炎症反应，提高拔管率及3、5 年生存率，并降低并发症发生率。

关键词：喉癌；保留喉功能手术；炎性因子

中图分类号：R739.65文献标志码：A文章编号：2096-1413(2017)21-0056-02

Clinical efficacy and safety of reservation of laryngeal function surgery in the treatment of laryngeal cancer
BAI Peng
(Fuping County Hospital, Weinan 711700, China)

ABSTRACT: Objective To investigate the clinical efficacy and safety of reservation of laryngeal function surgery in the treatment of laryngeal cancer. Methods A total of 86 laryngeal cancer patients who treated with surgery in our hospital were selected and randomly divided into observation group and control group, with 43 cases in each group. The control group was given total laryngectomy, and the observation group was given partial laryngectomy. The inflammatory levels, incidence of complications, decannulation rate, survival rate and recurrence rate of the two groups were compared. Results After surgery for 7 d, the levels of interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) of the observation group were lower than those of the control group (P<0.05). The incidence rate of complications of the observation group was 2.33%, which was lower than 18.60% of the control group; and the decannulation rate of the observation group was 88.37%, which was higher than 69.77% of the control group (P<0.05). The 3, 5 year survival rate of the observation group were 88.37%, 74.42% respectively, which were higher than 69.77% and 53.49% of the control group (P<0.05). There were no significant differences in 3, 5 year recurrence rate between the two groups (P>0.05). Conclusion Reservation of laryngeal function surgery in the treatment of laryngeal cancer can effectively reduce inflammatory response, improve the decannulation rate, 3, 5 year survival rate, and reduce the incidence rate of complications.
KEYWORDS: laryngeal cancer; reservation of laryngeal function; inflammatory factor

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