呋喃唑酮联合莫西沙星、埃索拉唑在根除幽门螺杆菌中的应用效果

李一鸣1，周新民2，孙菡2

（1.西安医学院第二附属医院消化内科，陕西 西安，710038；2.西京医院消化内科，陕西 西安，710032）

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摘要：

目的 探讨呋喃唑酮联合莫西沙星、埃索拉唑根除幽门螺杆菌（Hp）的效果。方法 对我院2012年8月至2016年8月收治的112例幽门螺杆菌感染患者的临床资料进行回顾性分析，以2014年8月前收治的56例幽门螺杆菌感染患者为对照组，采用埃索拉唑联合阿莫西林、克拉霉素治疗，将2014年8月后收治的56例幽门螺杆菌感染患者作为研究组，采用呋喃唑酮联合莫西沙星、埃索拉唑治疗，对比两组患者Hp清除率、复发率、症状消失时间及不良反应发生情况。结果 研究组患者治疗总有效率为92.86%（52/56），显著高于对照组的80.35%（45/56）（P<0.05）；研究组患者的Hp清除率显著高于对照组，复发率、症状消失时间均显著低于对照组（P<0.05）。研究组不良反应总发生率显著低于对照组（P<0.05）。结论 呋喃唑酮联合莫 西沙星、埃索拉唑能有效根除幽门螺杆菌，且复发率及不良反应少，安全可靠，值得推广应用。

关键词：呋喃唑酮；莫西沙星；埃索拉唑；幽门螺杆菌；复发率

中图分类号：R573 文献标志码：A文章编号：2096-1413(2017)21-0025-02

Application effect of furazolidone combined with moxifloxacin and esomeprazole in eradication of helicobacter pylori
LI Yi-ming 1, ZHOU Xin-min 2, SUN Han 2
(1. Department of Gastroenterology, the Second Affiliated Hospital of Xi``an Medical University, Xi``an 710038;
2. Department of Gastroenterology, Xijing Hospital, Xi``an 710032, China)

ABSTRACT: Objective To explore the clinical effect of furazolidone combined with moxifloxacin and esomeprazole in eradication of helicobacter pylori. Methods The data of 112 patients with helicobacter pylori infection admitted in our hospital from August 2012 to August 2016 was analyzed retrospectively. Fifty-six cases admitted before August 2014 were selected as control group and took esomeprazole combined amoxicillin and clarithromycin. Fifty-six cases admitted after August 2014 were classified as research group and took furazolidone combined moxifloxacin and esomeprazole. The clearance rate of Hp, recurrence rate, symptoms disappearance time and adverse reactions of the two groups were compared. Results The total effective rate of the research group was 92.86% (52/56), which was significantly higher than 80.35% (45/56) of the control group (P<0.05). The clearance rate of Hp in the research group was higher than that in the control group (P<0.05); the recurrence rate and symptoms disappearance time in the reseach group were lower than those in the control group (P<0.05); the incidence of adverse reactions in the research group was significantly lower than that in the control group (P<0.05). Conclusion Furazolidone combined moxifloxacin and esomeprazole in eradication of helicobacter pylori can effectively reduce helicobacter pylori, with lower recurrence rate and adverse reactions. In addition, it``s safe and reliable and can be popularized in clinic.

KEYWORDS: furazolidone; moxifloxacin; esomeprazole; helicobacter pylori; recurrence rate

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