低、高剂量米非司酮治疗功能失调性子宫出血临床对照研究

刘旭，倪晓荣

（定边县中医医院，陕西 榆林，718699）

浏览次数：51次 下载次数：409次

摘要：

目的 对比研究低、高剂量米非司酮治疗功能失调性子宫出血（DUB）的临床效果。方法 纳入我院收治的70例DUB患者作为研究对象，随机抽签将其分为观察组和对照组，各35 例。观察组患者给予周期性口服米非司酮6.25 mg/d，对照组患者连续口服米非司酮12.5 mg/d，两组疗程均为12周。比较两组的治疗效果和治疗前、后的卵巢功能和不良反应发生情况。结果 观察组与对照组治疗总有效率分别为88.57%和94.29%，组间无显著性差异（P>0.05）。观察组治疗后LH、FSH 及P 均显著低于治疗前和对照组（P<0.05）。观察组和对照组不良反应发生率分别为11.43%和34.29%，组间差异显著（P<0.05）。结论 低剂量周期性给予米非司酮能显著改善育龄DUB患者的出血症状和卵巢功能，且安全性高。

关键词：米非司酮；功能失调性子宫出血；LH；FSH

中图分类号：R711.52文献标志码：A文章编号：2096-1413(2017)20-0080-02

Clinical controlled study of low and high doses of mifepristone in the treatment of dysfunctional uterine bleeding
LIU XU, NI Xiao-rong
(Traditional Chinese Medicine Hospital of Dingbian County, Yulin 718699, China)

ABSTRACT: Objective To study the clinical effects of low and high does of mifepristone in the treatment of dysfunctional uterine bleeding (DUB). Methods Seventy cases of patients with DUB were selected and randomly divided into observation group and control group according to random drawing method, with 35 cases in each group. The observation group was given mifepristone 6.25 mg/d periodically, while the control group received continuous oral mifepristone 12.5 mg/d, the two groups were treated for 12 weeks. The treatment effects, ovarian function before and after treatment, incidence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group and the control group were 88.57% and 94.29% respectively, there was no significant difference between the two groups (P>0.05); the levels of LH, FSH and P in the observation group after treatment were lower than those before treatment and the control group (P<0.05); the incidence rate of adverse reactions in the observation group and the control group were 11.43% and 34.29% respectively, there was significant difference between the two groups (P<0.05). Conclusion Low dose periodic administration of mifepristone can significantly improve bleeding symptoms and ovarian function in women with DUB of childbearing age, and it has high safety.
KEYWORDS: mifepristone; dysfunctional uterine bleeding; LH; FSH

参考文献：
[1] 冉诗杰,冯小平.中西医结合治疗功能失调性子宫出血的护理[J]. 中国中医急症,2012,21(9):1544.
[2] 张娟,赵雪卉,李晓文,等.米非司酮与妈富隆治疗围绝经期功能失调性子宫出血的临床疗效观察[J].西北国防医学杂志,2012,33(3):201-203.
[3] 杨艳明,徐小凤,徐婉妍,等.低剂量米非司酮联合女金片治疗围绝经期功血的疗效观察[J].海南医学,2013,24(24):3633-3634.
[4] 乐杰.妇产科学[M].6 版.北京:人民卫生出版社,2004:330-337.
[5] 孙淑川,石颖.米非司酮与安宫黄体酮治疗围绝经期功血的疗效观察[J].河北医药,2011,40(20):3080-3081.
[6] 梁静,孙维峰,周建龙,等.中西医结合治疗围绝经期子宫出血的机制研究[J].中国中医急症,2013,22(7):1137-1139.
[7] 陈桂清,李成志.功能失调性子宫出血的发病机制及治疗进展[J].医学综述,2015,21(3):390-392.
[8] 王敏华,陈丽萍,谢榕,等.米非司酮与左炔诺孕酮对功能失调性子宫出血患者的疗效与安全性评价[J].中国临床药理学杂志,2015,31(6):453-455.
[9] MEI L,BAO J,TANG L,et al.A novel mifepristone-loaded implant for long-term treatment of endometriosis: in vitro and in vivo studies[J].Eur J Pharm Sci,2010,39(5):421-427.
[10] 孟燕,孙爱辉,赵芳,等.低剂量米非司酮联合去氧孕烯炔雌醇治疗无排卵型功能失调性子宫出血疗效观察[J].山东医药,2014,54(30):63-64.
[11] 杨琴.米非司酮治疗子宫内膜异位症的疗效及其机制探讨[J].山东医药,2013,53(48):52-53.
[12] 刘进.米非司酮对子宫内膜异位症患者卵巢功能及血清CA125、 HE4、CA199、炎性因子的影响[J].海南医学院学报,2012,18(11):1628-1630.
[13] 刘大庆,张瑜.米非司酮五日三周期疗法治疗围绝经期功血的临床疗效[J].现代妇产科进展,2012,21(2):138-141.
[14] 任月月,劳利迪.甲氨蝶呤联合米非司酮治疗异位妊娠的疗效及不良反应观察[J].中国基层医药,2014,21(18):2868-2869.
[15] 邹燕,李幼平,雷贞武,等.米非司酮配伍米索前列醇行药物流产的安全性评价[C]//全国现代妇产科学进展学术会议,2007:39-42.