纳米刀治疗肿瘤的基础研究
王越1, 2, 3,任冯刚1, 2 , 3 ,王浩华1, 2,吴荣谦1, 2,吕毅1, 2, 3
(1.西安交通大学先进外科技术与工程研究所;2.陕西省再生医学与外科工程研究中心; 3.西安交通大学第一附属医院肝胆外科,陕西 西安,710061)
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摘要:
<正>纳米刀(Nanoknife)技术于2012年经美国FDA批准进入临床肿瘤治疗领域,我国于2015年开始将该技术应用于临床。该技术利用陡脉冲高压电场(100 kV/cm级)对肿瘤进行电消融[1]。其原理是陡脉冲电场作用在细胞周围时,细胞膜表面形成纳米级别的缺损或孔洞使细胞膜通透性增加,该现象称为“电穿孔(electroporation)”;当陡脉冲电场增强时细胞膜 通透性会发生持续增加,最终导致细胞裂解,该现象称为“不可逆电穿孔(irreversible electroporation)”[2]。该技术的最大特点是高压电场破坏细胞的同时并不产生热量,并且对缺乏细胞成分的脉管组织基本无损伤,故近年来其作为一种新兴的肿瘤治疗手段被广泛研究。本文就纳米刀治疗肿瘤的相关基础研究热点问题进行述评。
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中图分类号:R735.7文献标志码:A文章编号:2096-1413(2017)07-0001-02
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