垂体后叶素联合米索前列醇、缩宫素在产后出血治疗中的临床观察

韦娟

（陕西省渭南市蒲城县中医院，陕西 渭南，715500）

浏览次数：126次 下载次数：355次

摘要：

目的 探讨垂体后叶素联合米索前列醇、缩宫素在产后出血治疗中的临床效果。方法 选择本院2013年7月至2016年4月收治的95例产后出血患者为研究对象，分成A组（48例）和B 组（47例）。B组患者给予常规治疗，主要为缩宫素肌肉注射或静脉滴注治疗，A组患者给予垂体后叶素联合米索前列醇、缩宫素治疗。比较两组产妇治疗后阴道出血量、子宫收缩和不良反应发生情况。结果 产后2、24h，两组患者阴道出血量均少于治疗前，且A组明显少于B组，差异有统计学意义（P<0.05）。A组患者的子宫收缩治疗总有效率是97.92%，明显高于B组的89.36%，差异有统计学意义（P<0.05）。A组患者的不良反应发生率为4.17%，明显低于B组的14.89%，差异有统计学意义（P<0.05）。结论 垂体后叶素联合米索前列醇、缩宫素在产妇产后出血的治疗中具有显著的临床疗效，可减少产后出血量，有利于子宫收缩，应在临床中推广。

关键词：垂体后叶素；缩宫素；米索前列醇；产后出血

中图分类号：R714.461文献标志码：A文章编号：2096-1413(2017)15-0078-02

Clinical observation of pituitrin combination with misoprostol and oxytocin in the treatment of postpartum hemorrhage
WEI Juan
(Traditional Chinese Medicine Hospital of Pucheng County, Weinan 715500, China)

ABSTRACT: Objective To investigate the clinical effect of pituitrin in combination with misoprostol and oxytocin in the treatment of postpartum hemorrhage. Methods Ninety-five cases of patients with postpartum hemorrhage admitted in our hospital from July 2013 to April 2016 were selected and divided into group A (48 cases) and group B (47 cases). Patients in the group A were treated with pituitrin in combination with misoprostol and oxytocin, while patients in the group B were treated with conventional treatment, mainly oxytocin intramuscular injection or intraverlows drip therapy. The vaginal bleeding, uterine contraction and adverse reactions of the two groups were compared. Results Two, 24 h after postpartum, the vaginal bleeding volum of the two groups were less than those before treatment, and that of the grup A were less than the group B (P<0.05). The total effective rate of uterine contraction of the group A was 97.92%, which was higher than 89.36% of the group B (P<0.05). The incidence rate of adverse reactions of the group A was 4.17%, which was lower than 14.89% of the group B (P<0.05). Conclusion Pituitrin in combination with misoprostol and oxytocin in the treatment for postpartum hemorrhage has remarkable clinical efficacy, it has less amount of vaginal bleeding and contributes to uterine contraction, which is worth of widely spreading in clinical practice.
KEYWORDS: pituitrin; oxytocin; misoprostol; postpartum hemorrhage

参考文献：
[1] 张志红.垂体后叶素、米索前列醇和缩宫素联合用药治疗产后出血的临床效果观察[J].中国社区医师,2015,31(11):43,45.
[2] 唐海彦.垂体后叶素、米索前列醇联合缩宫素治疗产后出血的疗效观察[J].临床合理用药杂志,2015,8(32):37-38.
[3] 钟荣钟.垂体后叶素、米索前列醇联合缩宫素治疗产后出血效果分析[J].海峡药学,2015,27(7):159-160.
[4] 鲍英丽.垂体后叶素、米索前列醇联合缩宫素治疗产后出血的临床分析[J].临床医学,2016,36(6):106-107.
[5] 蒋俐华,吴竟,金海英,等.垂体后叶素、米索前列醇和缩宫素联合治疗产后出血的临床观察[J].中国医药科学,2013,3(19):87-88,112.
[6] 张旭红.米索前列醇联合垂体后叶素治疗前置胎盘剖宫产后出血的疗效观察[J].中国实用医药,2013,8(6):131-132.
[7] 张彩丽.垂体后叶素、米索前列醇联合缩宫素治疗宫缩乏力性产后出血的效果分析[J].中国社区医师,2015,31(19):66,69.
[8] 王娜.垂体后叶素联合米索前列醇预防产后出血疗效观察[J].中国实用乡村医生杂志,2014,21(11):51-52.
[9] KUDIKINA NP.Effect of hormonal compounds on embryogenesis of the pond snail Lymnaea stagnalis (L.,1758)[J].Russ J Dev Biol,2011,42 (3):180-185.