不同剂量苯巴比妥对窒息患儿呼吸功能及脑损伤的疗效对比
唐萍,冯欢欢,刘莺
(西安高新医院,陕西 西安,710075)
浏览次数:203次 下载次数:432次
摘要:
目的 探讨不同负荷剂量苯巴比妥静注治疗窒息患儿的疗效。方法 选取我院2011年6月至2015年10月重症监护病房收治的重度窒息患儿60例,随机分为高负荷量组(给予高负荷量苯巴比妥静注治疗,30mg/kg)和低负荷量组(给予低负荷量苯巴比妥静注治疗,10mg/kg),各30例。对比两组患儿呼吸功能及脑损伤的恢复情况。结果 两组患者均存在呼吸功能障碍及脑损伤情况,其中,高负荷量组患儿的呼吸、反射、肌张力及意识恢复时间均短于低负荷量组,1周内症状完全消失率高于低负荷量组,死亡率低于低负荷量组(P<0.05)。结论 高负荷剂量苯巴比妥静脉注射治疗新生儿窒息,可更快促进呼吸功能及脑损伤的恢复。
关键词:窒息;苯巴比妥;呼吸障碍;脑损伤
中图分类号:R722.1文献标志码:A文章编号:2096-1413(2017)14-0097-02
Effect comparison of different dose of phenobarbital on respiratory function and brain injury on children with asphyxia
TANG Ping, FENG Huan-huan, LIU Ying
(Xi`an Gaoxin Hospital, Xi`an 710075, China)
ABSTRACT: Objective To investigate the curative effect of different doses of phenobarbital on the respiratory dysfunction and brain damage on children with asphyxia. Methods Sixty cases of children with severe asphyxia in our hospital of intensive care unitfrom from June 2011 to October 2015 were selected and randomly divide into high load group (received high dose of phenobarbital intravenous therapy, 30 mg/kg) and low load group (accepted low dose of phenobarbital intravenous therapy, 10 mg/kg), with 30 cases in each group. The recovery of respiratory function and brain injury in the two groups was compared. Results Respiratory dysfunction and brain damage existed in the two groups, the respiratory, reflect, muscular tension and consciousness recovery time in the high load group were shorter than those of the low load group, the complete disappearance of symptoms within 1 week was higher than that of the low-load group, the mortality rate was lower than that of the low load group (P<0.05). Conclusion High dose of phenobarbital intravenous injection on children with asphyxia has a faster respiratory function and brain damage recovery.
KEYWORDS: asphyxia; phenobarbital; respiratory dysfunction; brain damage
参考文献:
[1] 新生儿窒息多器官损害临床诊断多中心研究协作组.新生儿窒息多器官损害发生率、高危因素和转归的多中心研究[J].中华围产医学杂志,2016,19(1):23-28.
[2] 中华医学会围产医学分会新生儿复苏学组.新生儿窒息诊断的专家共识[J].中华围产医学杂志,2016,19(1):3-6.
[3] 王健民.苯巴比妥在新生儿窒息治疗中的临床应用[J].中国处方药,2014,12(10):54-55.
[4] 张缦莉,高帅.新生儿重度窒息后脑损伤的预防用药[J].中国实用医药,2015,10(23):180-181.
[5] 陈惠金,朱建安,陈冠仪,等.苯巴比妥预防新生儿重度窒息后颅内病变的对照研究[J].临床儿科杂志,1996,14(1):14.
[6] 甄艳芬.苯巴比妥在预防新生儿窒息后脑损伤及改善预后中的作用[J].中国妇幼保健,2007,22(22):3159-3160.
[7] 陈薇,董德敏.苯巴比妥静脉滴注在治疗新生儿窒息中的疗效观察及安全性分析[J].四川医学,2012,33(11):2000-2001.
[8] 陆映昭,邓晓麟,曾丽韫,等.苯巴比妥在新生儿窒息中的疗效观察[J].现代诊断与治疗,2016,27(8):1452-1454.
[9] 余健,邹敏书,聂国明,等.纳洛酮、苯巴比妥对重度窒息新生儿血浆 内皮素和丙二醛的影响[J].中国药师,2006,9(8):698-700.
[10] 母得志.新生儿缺氧缺血性脑病的早期治疗[J].中华妇幼临床医学杂志:电子版,2014,10(1):1-4.
[11] 邱华.新生儿缺氧缺血性脑病早期治疗及预后分析[J].中国当代医药,2011,18(22):178,181.
[12] 邓敏.苯巴比妥在防治新生儿窒息后脑损伤中的作用研究[J].河北医药,2012,34(6):840-841.